First Immune June 2016
Hamilton G, Rath B, Klameth L, Hochmair MJ.
300 SCIENTISTS ABOUT THE GCMAF
300 УЧЕНЫХ О GCMAF
По состоянию на июнь 2016 года только в Американской национальной медицинской библиотеке 180 выдающихся ученых из 8 стран повторно опубликовали 73 основные научные работы по GcMAF. С ними можно ознакомиться в правительственной системе США Pubmed.
Еще столько же работ опубликовано в других странах, так что во всем мире в общей сложности будет опубликовано около 140 научных работ 300 ученых.
В компании Immuno Biotech Ltd мы написали 33 исследовательские работы по GcMAF с 2012 года. Все они прошли экспертную оценку и опубликованы в престижных научных журналах или на конференциях по иммунологии. И они также размещены на этом сайте. На Pubmed есть только половина.
Вот список в Медицинской библиотеке США, http://www.ncbi.nlm.nih.gov/pubmed
при поиске по:
GcMAF OR DBPMAF OR » vitamin D binding protein» AND «macrophage activating factor»
1: Hamilton G, Rath B, Klameth L, Hochmair MJ. Small cell lung cancer:
Recruitment of macrophages by circulating tumor cells. Oncoimmunology. 2015 Oct
29;5(3):e1093277. eCollection 2016 Mar. PubMed PMID: 27141354; PubMed Central
PMCID: PMC4839345.
2: Delanghe JR, Speeckaert R, Speeckaert MM. Behind the scenes of vitamin D
binding protein: more than vitamin D binding. Best Pract Res Clin Endocrinol
Metab. 2015 Oct;29(5):773-86. doi: 10.1016/j.beem.2015.06.006. Epub 2015 Jul 2.
Review. PubMed PMID: 26522461.
3: Inui T, Kubo K, Kuchiike D, Uto Y, Nishikata T, Sakamoto N, Mette M. Oral
Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue
Syndrome: Three Case Reports. Anticancer Res. 2015 Aug;35(8):4545-9. PubMed PMID:
26168499.
4: Uto Y, Kawai T, Sasaki T, Hamada K, Yamada H, Kuchiike D, Kubo K, Inui T,
Mette M, Tokunaga K, Hayakawa A, Go A, Oosaki T. Degalactosylated/Desialylated
Bovine Colostrum Induces Macrophage Phagocytic Activity Independently of
Inflammatory Cytokine Production. Anticancer Res. 2015 Aug;35(8):4487-92. PubMed
PMID: 26168491.
5: Branca JJ, Morucci G, Malentacchi F, Gelmini S, Ruggiero M, Pacini S. Effects
of oxaliplatin and oleic acid Gc-protein-derived macrophage-activating factor on
murine and human microglia. J Neurosci Res. 2015 Sep;93(9):1364-77. doi:
10.1002/jnr.23588. Epub 2015 Mar 18. PubMed PMID: 25782915.
6: Morucci G, Branca JJ, Gulisano M, Ruggiero M, Paternostro F, Pacini A, Di
Cesare Mannelli L, Pacini S. Gc-protein-derived macrophage activating factor
counteracts the neuronal damage induced by oxaliplatin. Anticancer Drugs. 2015
Feb;26(2):197-209. doi: 10.1097/CAD.0000000000000177. PubMed PMID: 25304987.
7: Immunotherapy of metastatic colorectal cancer with vitamin D-binding
protein-derived macrophage-activating factor, GcMAF. Cancer Immunol
Immunother. 2014 Dec;63(12):1349.
8: ‘Immunotherapy of metastatic breast cancer patients with vitamin D-binding
protein-derived macrophage activating factor (GcMAF)’ by Yamamoto, N., Suyama,
H., Yamamoto, N. and Ushijima, N. Int J Cancer. 2014 Sep 15;135(6):1509. PubMed
PMID: 25180398.
9: Inui T, Makita K, Miura H, Matsuda A, Kuchiike D, Kubo K, Mette M, Uto Y,
Nishikata T, Hori H, Sakamoto N. Case report: A breast cancer patient treated
with GcMAF, sonodynamic therapy and hormone therapy. Anticancer Res. 2014
Aug;34(8):4589-93. Erratum in: Anticancer Res. 2015 Apr;35(4):2477. PubMed PMID:
25075104.
10: Ishikawa M, Inoue T, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T. A novel
assay system for macrophage-activating factor activity using a human U937 cell
line. Anticancer Res. 2014 Aug;34(8):4577-81. PubMed PMID: 25075102.
11: Ruggiero M, Ward E, Smith R, Branca JJ, Noakes D, Morucci G, Taubmann M,
Thyer L, Pacini S. Oleic Acid, deglycosylated vitamin D-binding protein, nitric
oxide: a molecular triad made lethal to cancer. Anticancer Res. 2014
Jul;34(7):3569-78. PubMed PMID: 24982371.
12: Siniscalco D, Bradstreet JJ, Cirillo A, Antonucci N. The in vitro GcMAF
effects on endocannabinoid system transcriptionomics, receptor formation, and
cell activity of autism-derived macrophages. J Neuroinflammation. 2014 Apr
17;11:78. doi: 10.1186/1742-2094-11-78. PubMed PMID: 24739187; PubMed Central
PMCID: PMC3996516.
13: Ikeda T, Kasai M, Tatsukawa E, Kamitakahara M, Shibata Y, Yokoi T, Nemoto TK,
Ioku K. A bone substitute with high affinity for vitamin D-binding
protein–relationship with niche of osteoclasts. J Cell Mol Med. 2014
Jan;18(1):170-80. doi: 10.1111/jcmm.12180. Epub 2013 Nov 28. PubMed PMID:
24286277; PubMed Central PMCID: PMC3916128.
14: Thyer L, Ward E, Smith R, Branca JJ, Morucci G, Gulisano M, Noakes D,
Eslinger R, Pacini S. GC protein-derived macrophage-activating factor decreases
α-N-acetylgalactosaminidase levels in advanced cancer patients. Oncoimmunology.
2013 Aug 1;2(8):e25769. Epub 2013 Jul 29. PubMed PMID: 24179708; PubMed Central
PMCID: PMC3812199.
15: Sayegh L, Fuleihan Gel-H, Nassar AH. Vitamin D in endometriosis: a causative
or confounding factor? Metabolism. 2014 Jan;63(1):32-41. doi:
10.1016/j.metabol.2013.09.012. Epub 2013 Oct 14. Review. PubMed PMID: 24135500.
16: Thyer L, Ward E, Smith R, Fiore MG, Magherini S, Branca JJ, Morucci G,
Gulisano M, Ruggiero M, Pacini S. A novel role for a major component of the
vitamin D axis: vitamin D binding protein-derived macrophage activating factor
induces human breast cancer cell apoptosis through stimulation of macrophages.
Nutrients. 2013 Jul 8;5(7):2577-89. doi: 10.3390/nu5072577. PubMed PMID:
23857228; PubMed Central PMCID: PMC3738989.
17: Inui T, Kuchiike D, Kubo K, Mette M, Uto Y, Hori H, Sakamoto N. Clinical
experience of integrative cancer immunotherapy with GcMAF. Anticancer Res. 2013
Jul;33(7):2917-9. PubMed PMID: 23780980.
18: Hirota K, Nakagawa Y, Takeuchi R, Uto Y, Hori H, Onizuka S, Terada H.
Antitumor effect of degalactosylated gc-globulin on orthotopic grafted lung
cancer in mice. Anticancer Res. 2013 Jul;33(7):2911-5. PubMed PMID: 23780979.
19: Kuchiike D, Uto Y, Mukai H, Ishiyama N, Abe C, Tanaka D, Kawai T, Kubo K,
Mette M, Inui T, Endo Y, Hori H. Degalactosylated/desialylated human serum
containing GcMAF induces macrophage phagocytic activity and in vivo antitumor
activity. Anticancer Res. 2013 Jul;33(7):2881-5. PubMed PMID: 23780974.
20: Toyohara Y, Hashitani S, Kishimoto H, Noguchi K, Yamamoto N, Urade M.
Inhibitory effect of vitamin D-binding protein-derived macrophage activating
factor on DMBA-induced hamster cheek pouch carcinogenesis and its derived
carcinoma cell line. Oncol Lett. 2011 Jul;2(4):685-691. Epub 2011 May 13. PubMed
PMID: 22848250; PubMed Central PMCID: PMC3406437.
21: Bellone M, Rigamonti N. Vitamin D-binding protein-derived
macrophage-activating factor, GcMAF, and prostate cancer. Cancer Immunol
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22: Uto Y, Yamamoto S, Mukai H, Ishiyama N, Takeuchi R, Nakagawa Y, Hirota K,
Terada H, Onizuka S, Hori H. β-Galactosidase treatment is a common first-stage
modification of the three major subtypes of Gc protein to GcMAF. Anticancer Res.
2012 Jun;32(6):2359-64. PubMed PMID: 22641675.
23: Pacini S, Punzi T, Morucci G, Gulisano M, Ruggiero M. Effects of vitamin
D-binding protein-derived macrophage-activating factor on human breast cancer
cells. Anticancer Res. 2012 Jan;32(1):45-52. PubMed PMID: 22213287.
24: Pacini S, Morucci G, Punzi T, Gulisano M, Ruggiero M, Amato M, Aterini S.
Effect of paricalcitol and GcMAF on angiogenesis and human peripheral blood
mononuclear cell proliferation and signaling. J Nephrol. 2012
Jul-Aug;25(4):577-81. doi: 10.5301/jn.5000035. PubMed PMID: 21956771.
25: Uto Y, Yamamoto S, Takeuchi R, Nakagawa Y, Hirota K, Terada H, Onizuka S,
Nakata E, Hori H. Effect of the Gc-derived macrophage-activating factor precursor
(preGcMAF) on phagocytic activation of mouse peritoneal macrophages. Anticancer
Res. 2011 Jul;31(7):2489-92. PubMed PMID: 21873164.
26: Debruyne E, Speeckaert M, Weygaerde YV, Delanghe J. Phenotype of Gc-globulin
influences the macrophage activating factor (MAF) levels in serum. Clin Chem Lab
Med. 2011 Nov;49(11):1855-60. doi: 10.1515/CCLM.2011.676. Epub 2011 Aug 23.
PubMed PMID: 21859424.
27: Pacini S, Morucci G, Punzi T, Gulisano M, Ruggiero M. Gc protein-derived
macrophage-activating factor (GcMAF) stimulates cAMP formation in human
mononuclear cells and inhibits angiogenesis in chick embryo chorionallantoic
membrane assay. Cancer Immunol Immunother. 2011 Apr;60(4):479-85. doi:
10.1007/s00262-010-0953-7. Epub 2010 Dec 14. PubMed PMID: 21170647.
28: Faserl K, Golderer G, Kremser L, Lindner H, Sarg B, Wildt L, Seeber B.
Polymorphism in vitamin D-binding protein as a genetic risk factor in the
pathogenesis of endometriosis. J Clin Endocrinol Metab. 2011 Jan;96(1):E233-41.
doi: 10.1210/jc.2010-1532. Epub 2010 Oct 27. PubMed PMID: 20980430.
29: Gregory KJ, Zhao B, Bielenberg DR, Dridi S, Wu J, Jiang W, Huang B,
Pirie-Shepherd S, Fannon M. Vitamin D binding protein-macrophage activating
factor directly inhibits proliferation, migration, and uPAR expression of
prostate cancer cells. PLoS One. 2010 Oct 18;5(10):e13428. doi:
10.1371/journal.pone.0013428. PubMed PMID: 20976141; PubMed Central PMCID:
PMC2956649.
30: Nonaka K, Onizuka S, Ishibashi H, Uto Y, Hori H, Nakayama T, Matsuura N,
Kanematsu T, Fujioka H. Vitamin D binding protein-macrophage activating factor
inhibits HCC in SCID mice. J Surg Res. 2012 Jan;172(1):116-22. doi:
10.1016/j.jss.2010.07.057. Epub 2010 Sep 17. PubMed PMID: 20855083.
31: Ravnsborg T, Olsen DT, Thysen AH, Christiansen M, Houen G, Højrup P. The
glycosylation and characterization of the candidate Gc macrophage activating
factor. Biochim Biophys Acta. 2010 Apr;1804(4):909-17. doi:
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32: Rehder DS, Nelson RW, Borges CR. Glycosylation status of vitamin D binding
protein in cancer patients. Protein Sci. 2009 Oct;18(10):2036-42. doi:
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33: Fang Y, van Meurs JB, Arp P, van Leeuwen JP, Hofman A, Pols HA, Uitterlinden
AG. Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int. 2009
Aug;85(2):85-93. doi: 10.1007/s00223-009-9251-9. Epub 2009 Jun 2. PubMed PMID:
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34: Yamamoto N, Ushijima N, Koga Y. Immunotherapy of HIV-infected patients with
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Jan;81(1):16-26. doi: 10.1002/jmv.21376.
35: Yamamoto N, Suyama H, Yamamoto N. Immunotherapy for Prostate Cancer with Gc
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36: Spiriti J, Bogani F, van der Vaart A, Ghirlanda G. Modulation of protein
stability by O-glycosylation in a designed Gc-MAF analog. Biophys Chem. 2008
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37: Yamamoto N, Suyama H, Nakazato H, Yamamoto N, Koga Y. Immunotherapy of
metastatic colorectal cancer with vitamin D-binding protein-derived
macrophage-activating factor, GcMAF. Cancer Immunol Immunother. 2008
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38: Yamamoto N, Suyama H, Yamamoto N, Ushijima N. Immunotherapy of metastatic
breast cancer patients with vitamin D-binding protein-derived macrophage
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39: Meier U, Gressner O, Lammert F, Gressner AM. Gc-globulin: roles in response
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40: Kalkunte S, Brard L, Granai CO, Swamy N. Inhibition of angiogenesis by
vitamin D-binding protein: characterization of anti-endothelial activity of
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41: Yamamoto N, Urade M. Pathogenic significance of
alpha-N-acetylgalactosaminidase activity found in the hemagglutinin of influenza
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42: Nagasawa H, Sasaki H, Uto Y, Kubo S, Hori H. Association of the macrophage
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44: Matsuura T, Uematsu T, Yamaoka M, Furusawa K. Effect of salivary gland
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45: Schneider GB, Grecco KJ, Safadi FF, Popoff SN. The anabolic effects of
vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel
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46: Mohamad SB, Nagasawa H, Sasaki H, Uto Y, Nakagawa Y, Kawashima K, Hori H. Gc
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48: Kisker O, Onizuka S, Becker CM, Fannon M, Flynn E, D’Amato R, Zetter B,
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51: Swamy N, Ghosh S, Schneider GB, Ray R. Baculovirus-expressed vitamin
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53: Odgren PR, Popoff SN, Safadi FF, MacKay CA, Mason-Savas A, Seifert MF, Marks
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54: Koga Y, Naraparaju VR, Yamamoto N. Antitumor effect of vitamin D-binding
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55: Adebanjo OA, Moonga BS, Haddad JG, Huang CL, Zaidi M. A possible new role for
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57: Yamamoto N, Naraparaju VR. Immunotherapy of BALB/c mice bearing Ehrlich
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58: Yamamoto N, Naraparaju VR, Moore M, Brent LH. Deglycosylation of serum
vitamin D3-binding protein by alpha-N-acetylgalactosaminidase detected in the
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